More COPD patients than you may realise need1...
inhealability
Some COPD inhalers require more inspiratory
effort than others.1*
SPIOLTO® RESPIMAT® was designed with inhaleability
in mind and to make it easy for your patients to inhale.2
References:
1. Ghosh S et al. Int J Chron Obstruct Pulmon Dis. 2019;14:585-595.
2. Anderson P et al. Int J Chron Pulmon Dis. 2006;1(3):251-259.
WISDOM trial suggests only a minority of COPD patients benefit from the addition of an ICS on top of Spiriva®+LABA, and these are clearly identifiable4
Document ID: PC-SG-100159
01/03/2019
Author: Boehringer Ingelheim
Long term ICS use is associated with systemic and local side effects.5-8 Data from WISDOM suggests that only a minority of patients will benefit from the addition of an ICS to LAMA/LABA. These patients have 3 characteristics - Severe/very severe airflow limitation, a history of ≥2 exacerbations per year & blood eosinophil ≥300 cells per μL.9
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References
1. Pitcairn G et al. J Aerosol Med 2005;3:264-272.
2. Anderson A. Int J Chron Obstruct Pulmon Dis 2006;1:251-259.
3. Dalby R et al. Med Devices: Evidence and Research 2011;4:145-155.
4. Magnussen H et al. N Engl J Med 2014;371(14):1285-1294.
5. Price D, et al. Prim Care Respir J 2013; 22: 92–100;
6. Global Initiative for Chronic Obstructive Lung Disease. Updated 2017. Available at: http://goldcopd.org/gold-2017-global-strategy-diagnosis-management-prevention-copd/;
7. Festic E, et al. COPD 2016; 13: 312–26;
8. Loke YK, et al. Thorax 2011; 66: 699–708.
9. Calverley PMA et al. Am J Respir Crit Care Med 2017. doi:10.1164/rccm.201612-2525LE
PC-SG-100210
Production date: Mar 2019
Production date: Mar 2019
What is Spiolto® Respimat® (tiotropium/olodaterol)?
Tiotropium/olodaterol is approved as once daily maintenance bronchodilator treatment to relieve symptoms in adult patients with COPD. It is built on tiotropium, the active ingredient in Spiriva® and is enhanced by olodaterol which was specifically designed to complement the efficacy of tiotropium. Tiotropium/olodaterol provides significant improvements in lung function, COPD symptoms and quality of life over tiotropium – right from the initial stages when suitable patients need maintenance therapy.[1-4]
Tiotropium/olodaterol is administered via Respimat®, the only inhaler available that actively delivers a unique mist. This means the patient just needs to take a slow deep breath to get the medication deep into the lungs.*[5-9]
Tiotropium/olodaterol is administered via Respimat®, the only inhaler available that actively delivers a unique mist. This means the patient just needs to take a slow deep breath to get the medication deep into the lungs.*[5-9]
What is the safety profile of Spiolto® Respimat® (tiotropium/olodaterol)?
Spiolto® Respimat® (tiotropium/olodaterol) has a comparable adverse event profile to the component monotherapies.[10]
Adverse event incidence was generally balanced across all treatment groups, with the majority being mild to moderate in severity.[10]
Spiolto® Respimat® safety and tolerability profile was established in patients treated for up to 52 weeks.[10]
The proportion of patients who discontinued due to adverse events with Spiolto® Respimat® was comparable to that of Spiriva® (tiotropium) and Striverdi® (olodaterol).[10]
The percentage of patients reporting an adverse event with Spiolto® Respimat® was comparable to that of Spiriva®.[10]
For full safety profile, please refer to the Local Prescribing Information.
What are the contraindications of Spiolto® Respimat® (tiotropium/olodaterol)?[4]
Spiolto® Respimat® is contraindicated in patients with hypersensitivity to tiotropium or olodaterol or to any of the excipients.
Spiolto® Respimat® is also contraindicated in patients with a history of hypersensitivity to atropine or its derivatives, e.g. ipratropium or oxitropium.
For information on warnings and precautions, please refer to the Local Prescribing Information.
Adverse event incidence was generally balanced across all treatment groups, with the majority being mild to moderate in severity.[10]
Spiolto® Respimat® safety and tolerability profile was established in patients treated for up to 52 weeks.[10]
The proportion of patients who discontinued due to adverse events with Spiolto® Respimat® was comparable to that of Spiriva® (tiotropium) and Striverdi® (olodaterol).[10]
The percentage of patients reporting an adverse event with Spiolto® Respimat® was comparable to that of Spiriva®.[10]
For full safety profile, please refer to the Local Prescribing Information.
What are the contraindications of Spiolto® Respimat® (tiotropium/olodaterol)?[4]
Spiolto® Respimat® is contraindicated in patients with hypersensitivity to tiotropium or olodaterol or to any of the excipients.
Spiolto® Respimat® is also contraindicated in patients with a history of hypersensitivity to atropine or its derivatives, e.g. ipratropium or oxitropium.
For information on warnings and precautions, please refer to the Local Prescribing Information.
References
[1] Maltais F et al. Effects of 12 weeks of once-daily tiotropium and olodaterol fixed-dose combination on exercise endurance in patients with COPD. Thorax 2014;69:A186-A187
[2] Ferguson F et al. Efficacy of tiotropium+olodaterol in patients with COPD by initial disease severity and treatment intensity: a post hoc analysis. Adv Ther. 2015; 32(6): 523-526
[3] Singh D et al. Tiotropium+olodaterol shows clinically meaningful improvements in quality of life. Respir Med. 2015; 10: 1312-1319
[4] Spiolto® Respimat® Summary of Product Characteristics, February 2017
[5] Newman SP et al. Lung deposition of fenoterol and flunisolide delivered using a novel device for inhaled medicines: Comparison of Respimat® with conventional metered-dose inhalers with and without spacer devices. Chest 1998; 113: 957-963
[6] Pitcairn G et al. Deposition of corticosteroid aerosol in the human lung by Respimat® Soft Mist™ Inhaler compared to deposition by metered dose inhaler or by Turbuhaler® dry powder inhaler. J Aerosol Med 2005; 18(3): 264-272
[7] Dalby R et al. A review of the development of Respimat® Soft Mist™ Inhaler. Int J Pharm 2004; 283: 1-9
[8] Dalby RN et al. Development of Respimat® SoftMist™ inhaler and its clinical utility in respiratory disorders. Med Devices (Auckl) 2011; 4: 145-155
[9] Anderson P. Use of Respimat Soft Mist Inhaler in COPD patients. Int J Chron Obstruct Pulmon Dis 2006; 1(3): 251–259
[10] Buhl R, et al. Eur Respir J. 2015;45:969-979.
[11] Spiriva® Respimat® Summary of Product Characteristics January 2017.
[12] Striverdi® Respimat® Summary of Product Characteristics March 2016.
[1] Maltais F et al. Effects of 12 weeks of once-daily tiotropium and olodaterol fixed-dose combination on exercise endurance in patients with COPD. Thorax 2014;69:A186-A187
[2] Ferguson F et al. Efficacy of tiotropium+olodaterol in patients with COPD by initial disease severity and treatment intensity: a post hoc analysis. Adv Ther. 2015; 32(6): 523-526
[3] Singh D et al. Tiotropium+olodaterol shows clinically meaningful improvements in quality of life. Respir Med. 2015; 10: 1312-1319
[4] Spiolto® Respimat® Summary of Product Characteristics, February 2017
[5] Newman SP et al. Lung deposition of fenoterol and flunisolide delivered using a novel device for inhaled medicines: Comparison of Respimat® with conventional metered-dose inhalers with and without spacer devices. Chest 1998; 113: 957-963
[6] Pitcairn G et al. Deposition of corticosteroid aerosol in the human lung by Respimat® Soft Mist™ Inhaler compared to deposition by metered dose inhaler or by Turbuhaler® dry powder inhaler. J Aerosol Med 2005; 18(3): 264-272
[7] Dalby R et al. A review of the development of Respimat® Soft Mist™ Inhaler. Int J Pharm 2004; 283: 1-9
[8] Dalby RN et al. Development of Respimat® SoftMist™ inhaler and its clinical utility in respiratory disorders. Med Devices (Auckl) 2011; 4: 145-155
[9] Anderson P. Use of Respimat Soft Mist Inhaler in COPD patients. Int J Chron Obstruct Pulmon Dis 2006; 1(3): 251–259
[10] Buhl R, et al. Eur Respir J. 2015;45:969-979.
[11] Spiriva® Respimat® Summary of Product Characteristics January 2017.
[12] Striverdi® Respimat® Summary of Product Characteristics March 2016.