GIOTRIF® : The 1st choice in 1st-line

GIOTRIF® :
The 1st choice in 1st-line

Superior efficacy vs gefitinib and vs chemotherapy
demonstrated in 3 large trials in 1st-line EGFR M+ NSCLC1-4*
 
UNCOMMON EGFR MUTATIONS DATABASE Click here to access
 

GIOTRIF® provides ≥3 years long-term response even with dose modification

Document ID: PC-MY-102595

04/08/2022

Author: Boehringer Ingelheim


Long-term responders (LTRs) to targeted therapeutics, remain on therapy for prolonged periods and show improved tumour responses.5
Identifying and determining the patient or tumour characteristics of this subset of patients is useful.

A post-hoc analysis of the LUX-Lung 3, 6 and 7 trials identified a subset of patients who received ≥3 years of GIOTRIF® treatment as LTRs.5

Patients treated for at least 2, 2.5 and 3 years in the Overall LL3/6/7 populations5

  • 10% patients in LL3 and LL6 and 12% patients in LL7 were identified as LTRs5
  • The proportion of LTRs was higher with GIOTRIF® (12%) vs gefitinib (4%) in LL75

Long-term GIOTRIF® treatment was independent of tolerability-guided dose adjustment5

  • A majority of the LTRs underwent tolerability-guided dose adjustments and yet could obtain sustained clinical benefit with GIOTRIF®5
  • Median (range) duration of treatment was 50 (41-73) months in LL3, 56 (37-68) months in LL6 and 42 (37-50) months in LL75
  • 75% (18/24) of LTRs in LL3 had tolerability-guided dose reduction of afatinib to <40 mg/day
  • mPFS was 49.5 months in LL3, mOS not reached with a median follow-up time of 64.6 months

References & Footnote:

1. Sequist LV et al. J Clin Oncol. 2013;31(27):3327-3334.
2. Wu YL et al. Lancet Oncol. 2014;15(2):213-22.
3. Yang JC et al. Lancet Oncol. 2015;16(2):141-51.
4. Park K et al. Lancet Oncol 2016;17(5):577–89.
5. Schuler M, et al. Lung Cancer. 2019;133:10-19.

EGFR M+=epidermal growth factor receptor mutation positive; LTR = long-term responder; NSCLC=non-small cell lung cancer; PFS=progression-free survival; OS=overall survival; LL3 = LUX-Lung 3; LL6 = LUX-Lung 6; LL7 = LUX-Lung 7.
* LUX-Lung 3 (vs pemetrexed/cisplatin) and LUX-Lung 6 (vs gemcitabine/cisplatin): superior PFS (primary endpoint) and superior OS in Del19 subgroup (secondary endpoint); LUX-Lung 7 (vs gefitinib): superior PFS (primary endpoint).

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PC-MY-102595
Production date: Aug 2022